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Data Availability All model parameters and kinetic information are presented in the supplementary information

NNMT Pathway Research Context Nicotinamide + SAM NNMT substrates NNMT Methyl-transfer enzyme targeted by 5-Amino-1MQ 1-MNA + SAH Reaction products Research interpretation: NNMT inhibition is studied for how reduced nicotinamide methylation may alter 1-MNA formation, nicotinamide partitioning, NAD + -salvage-related measurements, and cellular methyl-economy markers

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CD8 + T cells only differentiate into heterogeneous cytolytic T lymphocytes (CTLs), including tumoricidal effectors and long-term memory cells