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GLP-1 RA should be considered in all when no contraindications are present before initiation of insulin therapy, as they allow lower glycaemic targets to be reached with a lower injection burden and lower risk of hypoglycaemia and weight gain than with insulin alone

Semaglutide is one of the best new tools in his toolkit to help free his patients from the cycle of weight gain and obesity and the associated health risks excess weight brings

Elahi et al.Obesity (Silver Spring)

Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers