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Melanie Cree, professor at the University of Colorado Anschutz and lead author of the study, said the early findings suggest injectable semaglutide may help improve both areas simultaneously

While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]