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Fatigue may result from multiple factors including significant caloric deficit from appetite suppression, metabolic adaptation to weight loss, nutritional deficiencies, gastrointestinal side effects affecting food and fluid intake, and changes in blood glucose levels

In the OASIS 1 clinical trial, participants taking high-dose oral semaglutide (50mg) lost an average of 15.1% of their body weight over 68 weeks

Semaglutide helps lower blood sugar in several ways: Increases Insulin Release When you eat, semaglutide signals the pancreas to release more insulin

Diabetes: What Raises and Lowers Your Blood Sugar Level?Want to lower your blood sugar