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Safety and tolerability of dapagliflozin, saxagliptin and metformin in combination: Post-hoc analysis of concomitant add-on versus sequential add-on to metformin and of triple versus dual therapy with metformin
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Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation
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