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L-cysteine can be provided efficiently with N-Acetylcysteine (NAC)
The paratope of Fab 3F52 involves residues of all complementarity determining regions (CDRs) of both heavy and light chain variable regions (VH and VL), although the CDR3 loops appear to be responsible for the most critical interactions covering a major part of the hydrophobic interface
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Theres some research behind these ideas
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