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Mice born with liver-specific deletion of Gclc (using a Gclc f/f Albumin-Cre mouse strain) undergo liver failure and die shortly after birth 30
412 patients HIV lipodystrophy Falutz et al., N Engl J Med, 2007 Results at 26 weeks (2 mg SC/day) Component 1: Multicenter RCT, 2:1 ratio
Collectively, these studies suggest somewhat paradoxically that to maximize the induction of ferroptosis by GSH depletion it may be necessary to ensure that cancer cells are otherwise as metabolically active as possible
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