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Proliferation Assay Fresh isolated PBMCs or purified T/B cells labeled carboxyfluorescein succinimidyl ester (CFSE) were cultured with different concentration of L-Cn (Sigma-Aldrich) for 5 days in the presence of soluble anti-CD3 (5 g/mL, Biolegend) and anti-CD28 (5 g/mL, Biolegend) for T cell proliferation assay or 7 days in the presence of CPG (10 g/mL, InvivoGen) for B cell proliferation assay or with medium only as control
It is the only designated supplier of Korean LG in Japan
Emerging data suggests multi-agonist compounds may result in a different lean mass profile compared to GLP-1only peptides, although research is ongoing
This target trial emulation study compared GLP-1RAs with two other medications used in diabetes treatment: sodium-glucose cotransporter-2 inhibitors (SGLT2is) and dipeptidyl peptidase-4 inhibitors (DPP4is)
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