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Prospective Study of Grapefruit Intake and Risk of Breast Cancer in Postmenopausal Women: The Multiethnic Cohort Study. British Journal of Cancer, vol
Also, -viniferin reduced both the gene expression and circulating levels of leptin, a hormone that is produced by adipose tissue and helps regulate energy balance by suppressing appetite and increasing energy expenditure (Pico et al
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However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]
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