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Tirzepatide causes thyroid C-cell tumors in rats, and although its unknown whether tirzepatide causes thyroid C-cell tumors in humans, it is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
on the other side, non-cleavable linkers are formed by non-reducible bonds with the antibody amino-acid residues, leading to higher stability within the systemic circulation, and they release the payload through lysosomal-dependent degradation of the entire antibody-linker complex [14]
Glutathione is one of them
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