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2019;113:108768 Li JM, Chang WH, Li L, Yang DC, Hsu SW, Kenyon NJ, et al
In other words, if a pharmaceutical company thinks it can make a prescription drug out of a popular supplement ingredient, it can file a new drug application for a patented form of that ingredient, and the FDA will put out a letter stating that further sales of that ingredient in supplement form are prohibited
Before you can see tone changes from skin whitening products, you usually have to take therapeutic doses (5001000 mg daily) for 812 weeks
PMID 21920581
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