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Therefore, semaglutides effects on insulin could indirectly impact mental well-being by altering the gut microbiome

The RS-adjusted intervention effect was larger than the unadjusted intervention effect at 3 months (-1.97 [-1.84, -2.10] vs -1.58 [-1.48, -1.68]) and 12 months (-1.69 [-1.58, -1.81] Vs -1.41 [-1.32, -1.50]) with an attenuation of RS effect on the intervention effect over time