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Each time a cell divides, the DNA replication machinery cannot fully copy the very end of a linear chromosome a problem called the end replication problem resulting in the loss of 50-200 base pairs of telomeric DNA per division
Good news is, the fatigue usually fades as you adjust to the medication
Cancer Discov 2012
As estrogen levels decline, fat redistributes from subcutaneous areas to the abdomen, increasing cardiovascular and metabolic risks
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