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When essential protein components of the transport machinery are defective or missing, such as ADP-ribosylation factor 1 (ARF1), small GTP-binding protein 1 (SAR1), the guanine-nucleotide exchange factor Golgi-Brefeldin A resistance factor (GBF1), or the coatamer proteins coat-complex I (COPI) and COPII, ATGL translocation to LD is blocked and the enzyme remains associated with the ER
Excess methionine could lead to irritability or a powerful sulfur odor
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