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8 SCORE was a real-world study in the US that analyzed MACE outcomes among Wegovy (semaglutide) 2.4 mg users and non-users in real-world clinical practice, who met similar inclusion criteria as in the SELECT trial and were aged 45 years with overweight or obesity and established CVD without diabetes
The present application uses simple and low-cost mono-tert-butyl octadecanedioate as a starting material, provides a complete liquid-phase synthesis path for the side chain of semaglutide, and through cooperation of specific condensation reagents and activation reagents, proposes a reusable means for the activation reagent in the synthesis path for the first time
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