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Notably, older adults are more likely than their younger peers to have been told by a doctor that they have diabetes or heart disease
68 In contrast, subclonal neoantigens are confined to specific tumor subpopulations and are more likely to be retained under immune selection pressure, thereby serving as a major source of immune escape and relapse
This ensures the full dose delivers into the subcutaneous tissue and prevents medication from leaking back out through the injection site
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