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On the one hand, GPER not only decreases the expression of proinflammatory factors, mitigating inflammatory responses and increasing tumor cell survival rates, but also modulates the polarization of macrophages toward the M2 phenotype, thereby inhibiting tumor growth and metastasis [72]

doi: 10.1155/2016/3286365 32

Cagrilintide works through an entirely separate system, the amylin receptor pathway, targeting different neuronal populations in the brainstem that regulate satiety and appetite