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More injections and/or higher doses will be needed for better results

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The AEOL series and pentaazamacrocyclic ligand-based mimetics (SC series and M404 series), on the other hand, are more specialized toward O 2 (though many can also address other ROS as well) and generally lack catalase-like activity (targeted to eliminate H 2 O 2 ), and this may limit their therapeutic use (e.g., to more acute conditions such as lung injury or effects of ionizing radiation) (Day, 2008)