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The effect were seeing with GLP-1s isnt unique to the drugs, but to caloric restriction in general. Ultimately, Blau hopes that a PGDHi could become a standard companion to GLP-1 drugs, letting patients lose weight without sacrificing muscle
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Fibroblast growth factor 21 corrects obesity in mice
424,425,426,427 In addition to NADH produced in the mitochondria by the TCA cycle, cytoplasmic NAD + generation is essential for insulin secretion
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