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Tirzepatide Semaglutide (Ozempic/Wegovy) activates GLP-1 receptors, which: Slows stomach emptying Reduces appetite Improves insulin sensitivity Typically results in 15-20% weight loss over a year Tirzepatide (Mounjaro/Zepbound) activates both GLP-1 and GIP receptors, which: Provides all semaglutide benefits May have stronger effects on glucose metabolism Often results in 20-25% weight loss over a year Sometimes has fewer gastrointestinal side effects Your optimal choice depends on your specific PCOS presentation
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(Source: Heally, June 2026) Semaglutide Prescription Shift: Obesity Up 8%, Diabetes Down 6.4% Between March 2025 and June 2025, semaglutide prescriptions for treating diabetes decreased by 6.4% while prescriptions for obesity treatment increased by 8% in the same period
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