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This neuroinflammatory response not only contributes to disease progression, but also amplifies damage initiated by other pathological processes, such as protein aggregation, mitochondrial dysfunction, and synaptic failure
Systemic effects of GLP-1 RAs, mediated via GLP-1 receptors in other organs and systems, include enhanced endothelial function and myocardial metabolism, natriuresis and anti-inflammatory and blood pressure-lowering effects
Downside is possible
Toledo, Neusa Abelin, Michael A
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