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Preclinical work and early clinical trials indicate preferential intratumoral accumulation, sustained inhibition of topoisomerase I and hypoxia-inducible factor 1 alpha (HIF-1), and downregulation of HIF-1-related markers such as carbonic anhydrase IX in human tumor biopsies [90,91,92]
doi:10.1158/0008-5472.CAN-05-0808 Coriat R, Nicco C, Chreau C et al (2012) Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo
Eltrombopag and romiplostim may cause shortness of breath, coughing up blood, accelerated heart rate and breathing, dizziness or lightheadedness, and vision changes
When taken as directed, female hormone balance supplements are generally safe for healthy adults who arent pregnant or breastfeeding
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