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GSH deficiency makes cells more sensitive to oxidative stress and can cause degeneration of epithelial cells 50,51
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NO diffuses into adjacent smooth-muscle cells, stimulates soluble guanylate cyclase, increases cyclic GMP, and lowers intracellular calcium, culminating in vasorelaxation and anti-platelet effects
Weight loss and caloric restriction: For overweight or obese individuals, achieving 710% body weight reduction represents the primary therapeutic target
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