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Curiously in diabetic rats, it has recently been shown that this loop might indeed induce the production of more glucagon than in healthy animals (99)

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7.4.4 Next-generation agonists The development of dual GLP-1/GIP receptor agonists (e.g., tirzepatide) and novel blood-brain barrier-penetrant formulations may offer superior neuroprotective efficacy by more potently engaging central receptors or providing a broader spectrum of action (Ghaleb et al., 2025)

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