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Increased responsiveness of ventromedial hypothalamic neurons to norepinephrine in obese versus lean mice: relation to the metabolic syndrome
human), the nature and timing of stress exposure, brain region specificity, sex, cell type, gut microbiota composition, and age
Obesity is a complex metabolic disease
It identified legitimate methodological concerns (assay heterogeneity in the pharmacology comparison, Weber effect as a confounder in the FAERS analysis, uncertainty bounds on the efficacy extrapolation) and recommended specific textual revisions
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