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These mechanisms support the consistent findings with joint, gut, and soft tissue models
After IGF-1 treatment, immunohistochemistry and qRT-PCR were identified OA expression with changes in MMPs (matrix metalloproteinases)
doi:10.1200/JCO.2026.44.16_suppl.11000 Shah Z, Hundal J, Afridi SS, et al
The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo
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