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Targeting the key oxidative stress factors Dynamin-related protein 1 (DRP1) and NRF2, in thoracic cancer cells can restore cisplatin sensitivity while preventing the reactivation of metastasized cancer cells (Romani 2022)

[31] [32] [33] At a recommended maximum daily dose for an adult of three to four grams, [26] [34] paracetamol is safe and effective in the short term when used as directed, [35] with uncommon adverse effects similar to those of ibuprofen

in rats, under 30 minutes i.m

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb