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The SURMOUNT-1 trial was a randomized, double-blind, placebo-controlled study for which patients with overweight plus one weight-related comorbidity or obesity and without diabetes were randomly assigned to 72 weeks of tirzepatide 5 mg, 10 mg or 15 mg doses (Mounjaro/Zepbound, Eli Lilly) or placebo
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However, because this was a retrospective observational study, the findings cannot establish that higher semaglutide doses directly caused the improved cardiovascular outcomes, and unmeasured confounding factors may have influenced the observed associations
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