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Clinical trials and real-world studies consistently show that gastrointestinal symptomsnausea, vomiting, diarrhea and constipationare the most common side effects of GLP-1 receptor agonists.Harvard Health+3Nature+3PMC+3 In obesity trials in particular, constipation often shows up more frequently than it does in type 2 diabetes trials.Taylor & Francis Online+1 As a nutritionist who works every day with people struggling with IBS, chronic constipation, bloating and other functional digestive issues, Im seeing more and more clients who are also using GLP-1 medications

It's a direct chemical approach that works exactly where it's injected and nowhere else

Long-term use of Semaglutide is generally considered safe for its approved uses, though ongoing monitoring for side effects is recommended

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