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The study by Cacciari and colleagues showed that the factors regulating GH secretion during sleep may differ from those that influence GH secretion during wakefulness ( It was encouraging to see data showing some sleep improvements when children with GHD are treated with GH replacement therapy ( Given the association between GHD and sleep disturbances in both adults and children, and acknowledged limitations in the current diagnostic processes ( The key limitation of the current review was the low availability and quality of the published data on the effects of GH on sleep in children