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National Institute for Health and Care Excellence (NICE) criteria for initiation of GLP-1 and GIP analogues is as follows: if triple therapy with metformin and two other oral drugs is not effective, not tolerated or contraindicated, consider triple therapy by switching one drug for a GLP-1 analogues for adults with T2DM who have a body mass index (BMI) of 35kg/m 2 or higher[15]
Red flag symptoms requiring urgent medical attention include reduced urine output with swelling (suggesting acute kidney injury), blood in the urine (haematuria), fever with urinary symptoms (indicating possible pyelonephritis), or signs of severe dehydration such as dizziness, confusion, or rapid heartbeat
Small timing differences are generally acceptable
The timing varies based on procedure type, post-operative complications, and individual patient factors
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