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Important Safety Information Pregnancy or breastfeeding (hard contraindication for estriol-containing formulas) Hormone-sensitive cancer history (ER-positive breast, endometrial) flags estriol formulas for provider review Known copper allergy (GHK-Cu formulas) Open wounds, broken skin, or active infection at application site Wilson's disease or other copper-handling disorder (flag for provider review) Current SSRI, SNRI, MAOI, or TCA therapy (flag for methylene blue cream review) Frequently asked questions about skin & hair peptides What do peptides do for skin

Croll, T

B12 plays a critical role in energy metabolism and the production of red blood cells, which are essential for delivering oxygen to your muscles

Todorov on smartskincare writes this: "..excessive use can have an opposite effect by increasing the levels of free copper and/or by triggering excessive production of metalloproteinases