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Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC, an absorption enhancer for RYBELSUS , and because there are alternative formulations of semaglutide that do not contain SNAC that can be used during lactation, advise patients that breastfeeding is not recommended during treatment with RYBELSUS Please click here for RYBELSUS Prescribing Information, including Boxed Warning
However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.
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