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Deleterious Effects of Astrocytes on Remyelination A transcriptomic analysis of astrocytes activated by different types of insults (ischemia, LPS injection) revealed that two types of reactive astrocytes could be distinguished: A1 astrocytes with detrimental effects on cell survival and regeneration and A2 astrocytes presenting protective effects (Zamanian et al., 2012)

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The emergence of glucagon-like peptide-1 (GLP-1) receptor agonists represents one of the most significant advances in obesity and diabetes treatment in recent decades