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However, some patients experience persistent constipation throughout treatment, particularly at higher doses

The principal neurological function regulated by GLP-1RA could be summarized as follows ( Figure 2 ): (1) GLP-1RA liraglutide and exendin-4 effectively inhibited neuronal apoptosis ( Figure 2 4 GLP-1RA reduced the risk of stroke in T2D patients clinically As a new type of hypoglycemic drug, GLP-RAs are currently mainly used in clinical practice to evaluate the prognosis of various complications in T2D patients, such as stroke, kidney injury, fatty liver, and cardiovascular disease (43)

Our results should be seen in light of several (additional) limitations, the most important of which is that their cross-sectional nature precludes any assessment of a causal relationship between metabolic health and motivation

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