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These hormones play a role in regulating blood sugar by stimulating insulin release and inhibiting glucagon release from the pancreas [7]
The TRAVERSE Trial The Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy Response in Hypogonadal Men (TRAVERSE) trial, published in The New England Journal of Medicine in 2023, enrolled 5,246 men aged 45 to 80 with hypogonadism and preexisting or high risk of cardiovascular disease [3]
HOTAIR (HOX transcript antisense intergenic RNA), a well-known lncRNA, sponges miR-1 and induces CCND2 expression or interacts with polycomb repressive complex 2 (PRC2) or lysine-specific histone demethylase 1 (LSD1) to regulate H3K27 trimethylation and H3K4 demethylation, respectively [172, 173]
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