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In addition, these models showed decreased levels of lysosomal proteins and enzymes and altered autophagy, suggesting that increased cellular iron levels and oxidative stress are accompanied by mitochondrial abnormalities, autophagic defects, and diminished lysosomal function [155, 156]

A fragile redox state within the mitochondria of individuals with autism has been previously reported, 48 and may reflect a self-amplifying cycle of antioxidant depletion and aconitase inactivation

Tyni T, et al

This includes individuals with medical conditions such as pernicious anemia, atrophic gastritis, celiac disease, or Crohns disease, all of which can interfere with B12 absorption