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Keap1 is a cysteine-rich protein that can be oxidized by ROS and results in conformational change, which in turn liberates NRF2
Cell lines PC12 cells carrying doxycycline-inducible SNCA A53T were maintained in DMEM (high glucose) medium containing 10% heat-inactivated horse serum and 5% FBS
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Free radicals are unstable molecules that are missing an electron
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