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Semaglutide activates one receptor (GLP-1)

The peptide appears to promote tenocyte proliferation and enhance extracellular matrix synthesis, leading to improved biomechanical properties of repaired tissues

Looking Ahead Retatrutide is still investigational

Members at or near goal weight optimizing body composition Patients who tolerated standard GLP-1 dosing poorly but want the metabolic benefit Members layering the protocol into a coordinated primary care or mental health strategy Patients with significant weight to lose who would be better served by a standard GLP-1 protocol Personal or family history of medullary thyroid carcinoma or MEN 2 Pregnancy, breastfeeding, or planning pregnancy Expected Timeline What to Expect Microdosing is measured in composition, energy, and how you feel not weekly weigh-ins