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Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs
10.1242/jcs.115972 81 DimmelerS.FlemingI.FisslthalerB.HermannC.BusseR.ZeiherA
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