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The updated 2018 diagnostic criteria for PCOS require the presence of at least two of the following three features: (1) oligo/anovulation, (2) clinical and/or biochemical hyperandrogenism, and (3) PCO identified by the presence of 20 antral follicles per ovary on transvaginal ultrasound, with or without increased ovarian volume
Mimura EC, Bregano JW, Dichi JB, Gregorio EP, Dichi I
A: Small studies have reported changes in melanin-related measurements or skin brightness, but findings are inconsistent and study sizes are limited
Review the evidence on hepatotoxicity, ALT/AST levels, and safe dosing protocols
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