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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

Signalling activates PLC- DAG + IP3 intracellular Ca + PKC (via Gq) plus Gs-cAMP-PKA, with a balanced profile neither Gs- nor -arrestin-biased in recent cryo-EM and BRET studies (2020-2023)

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In addition, this active site motif assists in methylation of inorganic toxic form, As(III), to organic form monomethylarsonic acid (MMA) ( Consequently, these unique properties of GSTs make them important and interesting area of research for the functional characterization