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However, we also expect future guidelines to provide more detailed interpretations of the cardiovascular benefits of metformin and peculiar therapy recommendations for T2DM patients with higher risk of MACE, which should be independent of other cardiovascular outcomes

For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids

Berberine more commonly causes the opposite: loose stools, cramping, or diarrhea, especially when started at a full dose

Effects when activated: Stimulate insulin secretion from pancreatic beta cells Inhibit glucagon secretion from pancreatic alpha cells Slow gastric emptying Increase satiety (feeling of fullness) Potential neuroprotective effects in the brain GIP Receptors: Function: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors respond to the hormone GIP