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Acknowledgements This study was supported by National Key Research and Development Plan Precision Medicine Research (2017YFSF090203), the National Natural Science Foundation of China (81470840, 81873565 and 81800510), Shanghai Sailing Program (18YF1415900), VA Merit Award (I01BX004033 and I01BX001390), and Research Career Scientist Award (IK6BX004477)
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