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In this regard, the activity of the nutrient/stress-sensing mTORC1 is increased during periods of nutrient abundance, and is conversely inhibited when under nutrient stress, such as reduced intracellular ATP or reduced amino acid availability
It has to be removed from the brain extracellular fluid through EAATs transporters (the most powerful of the active transporters) present in astrocytes (EAAT1-3), neurons (EAAT3) and at the abluminal side of the BBB (EAAT1-3) and through systems Xc and X G in the luminal membrane
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