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They work through different mechanisms and have very different risk profiles
Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)
10.1096/fj.02-0508fje FASEB J
Tirzepatide impressive weight loss as compared to Semaglutide, was because it was a more potent GLP-1 or because of synergistic effect of GIP
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