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Description

GSR glutathione reductase Cys63 nucleophilically attacks the sulfide of Cys58, releasing a GS-anion, which, in turn, picks up a solvent proton and is released from the enzyme, thereby creating the second GSH

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The 2008 Lancet trial that established tesofensine's efficacy also documented cardiovascular adverse events in 18% of participants at the 1mg dose

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