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Autophagy is an intracellular degradation process responsible for eliminating proteins, misfolded or damaged organelles, and aged cellular components

United States Census Bureau, Population Division

Serrano MA, Moreno JC

Overall, Trp metabolism influences the functional spectrum of macrophages through two intertwined pathways, namely the stress response induced by Trp depletion and the AhR signaling mediated by Kyn/indole derivatives. The overall outcome is often manifested as restriction of pro-inflammatory programs and support of immunoregulatory/tolerance-related phenotypes, although this effect is condition-dependent and influenced by ligand source (host or microbial), inflammatory stage, and the tissue microenvironment