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Addressing the issue, the Health chief stressed the importance of health education as a key component in combating the misuse of such treatments

Oxidative stress can promote 4-hydroxy-2-nonenal (4-HNE)-mediated modification of HSPA2, targeting it for degradation through the ubiquitin-proteasome system, which may lead to the loss of proteins required for meiosis and contribute to spermatogenic arrest ( Furthermore, multiple studies have demonstrated that heat stress-induced spermatogenic dysfunction 209 is closely associated with germ cell apoptosis, which displays both cell-type- and stage-specific 210 characteristics (Figure 1c) (Lue et al., 1999

Single-Center Study Natalia Rojas-Amaris, Ana Marenco-Flores, Carmen Lara-Romero, Romelia Barba, Denisse Rubio-Cruz, Ximena Parraga, Daniela Goyes, John Esli Medina-Morales, Leandro Sierra, Manuel Romero-Gomez, Michelle Lai, Behnam Saberi, Vilas Patwardhan, Alan Bonder Journal of Clinical Medicine .2025