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insulin is broken down by the stomach acid Concentration the higher the concentration, the more drug that is absorbed (usually!) Ionisation ionised particles cannot diffuse across membranes this plays a part in the mechanism of action for local anaesthetics Solubility drugs that are more polar (see below) are less readily absorbed through the lipid bilayer of the cell membrane Physical state of the drug e.g

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Gel-One is a unique formulation among hyaluronic acid derivatives because it requires only a single intra-articular injection rather than a series of multiple treatments